Current issue – 03/2024
Chronic non-bacterial osteomyelitis (CNO) in childhood and adolescence – a disease with many faces
Steinborn M, Huf V
Chronic non-bacterial osteomyelitis (CNO) is a chronic inflammatory skeletal disease that affects particularly children and adolescents and is often diagnosed with a delay. With whole-body MRI, early diagnosis of this disease is possible in many cases. Since children and adolescents frequently present with non-specific complaints for outpatient radiological diagnosis, every radiologist should have basic knowledge of this complex clinical picture.
Forensic Diagnostics of the Skeletal Age in the Living – Backgrounds and Methodology
Wittschieber D, Hahnemann ML, Mentzel HJ
Considering recent scientific knowledge, the current conditions and established skeletal age diagnostics methods are presented. Additionally, this review article sheds light on the influence of ethnicity and socioeconomic status, questions regarding indication, as well as alternative and future developments.
Imaging-based characterization of tumoral heterogeneity for personalized cancer treatment
Haag F, Hertel A, Tharmaseelan H et al.
With personalized tumor therapy, understanding and addressing the heterogeneity of malignant tumors is becoming increasingly important. Heterogeneity can be found within one lesion (intralesional) and between several tumor lesions emerging from one primary tumor (interlesional). The heterogeneous tumor cells may show a different response to treatment due to their biology, which in turn influences the outcome of the affected patients and the choice of therapeutic agents. Therefore, both intra- and interlesional heterogeneity should be addressed at the diagnostic stage.